Nicolas Touret (PhD, Nice/Sophia Antipolis University)

Associate Professor Nicolas Touret

Department of Biochemistry
School of Translational Medicine
Faculty of Medicine & Dentistry
University of Alberta
4-020H Katz Group – Rexall Centre for Pharmacy and Health Research
Edmonton, Alberta, Canada  T6G 2E1 

Tel: 780.492.3513
Lab Tel: 780.492.0209
Fax:  780.492.0886

Research Description

The laboratory is focused on elucidating the molecular mechanisms involved in the initiation of immune responses when the organism is challenged with pathogens.

The laboratory is focused on elucidating the molecular mechanisms involved in the initiation of immune responses when the organism is challenged with pathogens.

We are using new imaging technologies, capable of resolving the behavior of single molecules, to define the change of state overtime that receptors of innate immune cells (macrophages and dendritic cells) are undergoing during their interaction with pathogen’s molecules.

Selected publications 

Lipinski, T.*, Fitieh, A.*, St. Pierre, J., Ostergaard, H.L., Bundle, D.R. and Touret, N. (2013) Enhanced Immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to DCs via Dectin-1 by incorporating b-glucan.  J Immunol. [Epub ahead of print]

Goodridge, H. S., Underhill, D. M., & Touret, N. (2012). Mechanisms of fc receptor and dectin-1 activation for phagocytosis. Traffic13(8), 1062–1071.

Haile Y., Simmen K.C., Pasichnyk D., Touret N., Simmen T., Lu J.Q., Bleackley R.C., Giuliani F .  (2011)  Granule-Derived Granzyme B Mediates the Vulnerability of Human Neurons to T Cell-Induced Neurotoxicity.  J Immunol9(187):(4861-72). Impact Factor: 5.75

Prins D., Groenendyk J., Touret N, Michalak M.   (2011)  Modulation of STIM1 and capacitative Ca(2+) entry by the endoplasmic reticulum luminal oxidoreductase ERp57. EMBO Rep. 11(12):(1182-8). Impact Factor: 7.82 

Jaqaman K., Kuwata H., Touret N, Collins R., Trimble W.S., Danuser G., Grinstein S.  (2011)  Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function. Cell146(4):(593-606). Impact Factor: 32.4